【摘要】 通过Ｌ－赖氨酸（Ｎ￣１－５－氟尿嘧啶）烷基酯双盐酸盐与二氯磷酸乙酯、二氯膦甲酸乙酯、二氯膦乙酸乙酯共聚，合成了三类１２种侧链含５－氟尿嘧啶的聚磷酰胺。聚合物的结构经ＵＶ、ＩＲ、１ＨＮＭＲ及元素分析鉴定。聚合物用微量细胞培养四氮唑实验方法（ＭＴＴ法）进行了对人肝癌细胞系Ｂｅｌ－７４０２细胞的微量培养实验。更多还原

【Abstract】 Twelve biodegradable polyphosphamides containing both 5-FU and phosphonoformic acid(or phosphonoacetic acid) ethyl ester were synthesized by condensation of L-lysine 5-FU alkyl(n=3,4,5,6)ester dihydrocmorides with dichloropliosplioric acid ethyl ester,dichlorophosphonoformic acid ethyl ester or dichlorophosphonoacetic acid ethyl ester,respectively,in DMF and in the presence of triethylamine. The drug release tests were studied in different pH media. Antitumor activities of monomer and polymers were tested against human hepatoma Bel-7402 cells in vitro.更多还原